MEGUIAR'S M47 - Manual (Page 8)

M47, Hard Water Spot Remover (18-151B): M4716
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Carcinogenicity
Name Route Species Value
Citric Acid Ingestion Rat Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Citric Acid Ingestion Not toxic to female reproduction Rat NOAEL 600
mg/kg/day 2 generation
Citric Acid Ingestion Not toxic to male reproduction Rat NOAEL 600
mg/kg/day 2 generation
Citric Acid Ingestion Not toxic to development Rat NOAEL 600
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Citric Acid Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification NOAEL Not
available
Mixture of 5-chloro-2-
methyl-2H-isothiazol-3-
one and 2-methyl-2H-
isothiazol-3-one Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification similar
health
hazards NOAEL Not
available
Specific Target Organ Toxicity - repeated exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Citric Acid Ingestion bone, teeth, nails,
and/or hair Some positive data exist, but the
data are not sufficient for
classification Rat NOAEL 600
mg/kg/day 90 days
Citric Acid Ingestion endocrine system |
hematopoietic
system Some positive data exist, but the
data are not sufficient for
classification Rat NOAEL
4,670
mg/kg/day 6 weeks
Citric Acid Ingestion kidney and/or
bladder Some positive data exist, but the
data are not sufficient for
classification Rat NOAEL
1,300
mg/kg/day 6 weeks
Aspiration Hazard
Name Value
Please contact the address or phone number listed on the first page of the SDS for additional toxicological information
on this material and/or its components.
SECTION 12: Ecological information