MEGUIAR'S D181 - Manual (Page 8)

D181, Leather Cleaner (24-45B): D18101
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Solvent naphtha (petroleum), light
aliphatic Dermal Mouse Some positive data exist, but the data
are not sufficient for classification
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure Duration
Sodium Metasilicate Ingestion Some positive
developmental data
exist, but the data are
not sufficient for
classification Mouse NOAEL 200
mg/kg/day during gestation
Sulphonic acids,
C14-16-alkane
hydroxy and C14-16-
alkene, sodium salts Ingestion Not toxic to female
reproduction Rat NOAEL 871
mg/kg 2 generation
Sulphonic acids,
C14-16-alkane
hydroxy and C14-16-
alkene, sodium salts Ingestion Not toxic to male
reproduction Rat NOAEL 891
mg/kg 2 generation
Sulphonic acids,
C14-16-alkane
hydroxy and C14-16-
alkene, sodium salts Ingestion Some positive
developmental data
exist, but the data are
not sufficient for
classification Rabbit NOAEL 600
mg/kg during organogenesis
Solvent naphtha
(petroleum), light
aliphatic Data not available or
insufficient for
classification
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target
Organ(s) Value Species Test result Exposure
Duration
Sodium
Metasilicate Inhalation respiratory
irritation May cause
respiratory
irritation official
classification NOAEL Not
available
Sulphonic
acids, C14-
16-alkane
hydroxy and
C14-16-
alkene,
sodium salts Data not available
or insufficient for
classification
Solvent
naphtha
(petroleum),
light aliphatic Inhalation central nervous
system
depression May cause
drowsiness or
dizziness NOAEL Not
available
Solvent
naphtha
(petroleum),
light aliphatic Inhalation respiratory
irritation Some positive
data exist, but the
data are not
sufficient for
classification NOAEL Not
available
Specific Target Organ Toxicity - repeated exposure
Name Route Target
Organ(s) Value Species Test result Exposure
Duration
Sodium
Metasilicate Ingestion kidney and/or
bladder Some positive
data exist, but the
data are not Dog LOAEL 2,400
mg/kg/day 4 weeks