MEGUIAR'S D156 User Manual

Page 6

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D156, Express Spray Wax (DX-93B)

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Page: 6 of 12

Acute Toxicity

Name

Route

Species

Value

Overall product

Ingestion

No data available; calculated ATE >5,000 mg/kg

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one

Dermal

Rabbit

LD50 87 mg/kg

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one

Inhalation-
Dust/Mist
(4 hours)

Rat

LC50 0.33 mg/l

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one

Ingestion

Rat

LD50 40 mg/kg

ATE = acute toxicity estimate

Skin Corrosion/Irritation

Name

Species

Value

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one

Rabbit

Corrosive

Serious Eye Damage/Irritation

Name

Species

Value

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one

Rabbit

Corrosive

Skin Sensitisation

Name

Species

Value

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one

Human
and
animal

Sensitising

Photosensitisation

Name

Species

Value

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one

Human
and
animal

Not sensitizing

Respiratory Sensitisation

Name

Species

Value

Germ Cell Mutagenicity

Name

Route

Value

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one

In vivo

Not mutagenic

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one

In Vitro

Some positive data exist, but the data are not
sufficient for classification

Carcinogenicity

Name

Route

Species

Value

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one

Dermal

Mouse

Not carcinogenic

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one

Ingestion

Rat

Not carcinogenic

Reproductive Toxicity

Reproductive and/or Developmental Effects

Name

Route

Value

Species

Test result

Exposure
Duration

Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one

Ingestion

Not toxic to female reproduction

Rat

NOAEL 10
mg/kg/day

2 generation

Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-

Ingestion

Not toxic to male reproduction

Rat

NOAEL 10
mg/kg/day

2 generation

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