ALESIS MULTIMIX USB2.0 - Manual (Page 38)

5 USB2.0 Recording
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7. You will do most of your monitoring through the mixer.
However, if you want to monitor with Cubase’s effects, or if
you just want to hear what the computer is hearing, press the
direct monitoring button next to the Record Enable button.
Note that using direct monitoring causes a small delay as the
digital audio is being processed. For this reason, when you
use direct monitoring, you may want to press the MultiMix’s
MIX TO CONTROL ROOM button up so as not to hear
the audio signal twice.
8. Add additional audio tracks as needed. Record-arm each one
and press the RECORD button to begin recording.
For additional information, consult your software’s documentation.