FORD 2010 E-450 v.2 - Manual (Page 240)

Tire change procedure
WARNING: To help prevent the vehicle from moving when you
change a tire, be sure the parking brake is set, then block (in
both directions) the wheel that is diagonally opposite (other side and
end of the vehicle) to the tire being changed.
WARNING: If the vehicle slips off the jack, you or someone else
could be seriously injured.
WARNING: Do not attempt to change a tire on the side of the
vehicle close to moving traffic. Pull far enough off the road to
avoid the danger of being hit when operating the jack or changing the
wheel.
Note: Passengers should not remain in the vehicle when the vehicle is
being jacked.
1. Block the wheel that is diagonally opposite the tire you are changing.
On E-450 vehicles, the parking brake is on the transmission. Therefore,
the vehicle will not be prevented from moving when a rear wheel is
lifted, even if the parking brake is applied. Be sure to block both
directions of the wheel that is diagonally opposite to the wheel that is
being lifted.
2. Remove the spare tire and jack from the storage location.
Roadside Emergencies
240
2010 Econoline (eco)
Owners Guide, 2nd Printing
USA (fus)