IOGear GKM521R - Manual (Page 30)

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Once you have assigned a function to each
mouse button, simply click OK to apply the
changes.
Tip: If you wish to assign a different function to
the mouse buttons in the future, simply follow the
same procedure and select a different function
for each button. If you wish to disable any of the
buttons (3, 4, 5), simply set that button to
“System Default.” 6.
Mouse Configureation