Asus P5B - Manual (Page 37)

ASUS TeleSky User Manual 
Check the checkboxes against the TeleSky settings you wish
to enable.
If you check these two checkboxes, everytime you start-
up the windows, the TeleSky utility and Skype will start
automatically.
Once all settings have been completed, click Apply and OK
to save all changes.
Changing TeleSky Settings