Asus Maximus Extreme - Manual (Page 185)

ASUS Maximus Extreme 6-9
To enable CrossFire™:
1. Set the view to Advance.
2. Click the Crossfire™ item in Graphics Settings.
3. In the CrossFire™ Settings dialog, tick the box opposite Enable
CrossFire™.
4. Click OK to effect the setting.
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Hotkeys
Click the Hotkeys tab on the Catalyst™ Control Center to access the Hotkeys
Manager, which allows you to create key combinations as shortcuts for
performing certain functions quickly.