HP Storage Mirroring Software - Manual (Page 274)

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You must disable protection before you can change any of the Application Manager
configuration parameters.
1. If you select a source that is already protected in the Source Server field, the
target server will be filled in automatically and the Protection Status should
indicated Protected.
2. Click Disable Protection at the bottom of the window, or select Actions, Disable
Protection, to disable protection.
Next step: Enable protection