Immunoreactivity – normal panel – Leica Biosystems Bond Oracle HER2 IHC System User Manual

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Page 17 of 23

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Leica Biosystems Bond Oracle HER2 IHC System Instructions for Use TA9145 EN-CE-Rev_E 18/06/2013

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Immunoreactivity – Normal Panel

Normal Tissue Type

Staining Pattern

HER2 Primary Antibody

HER2 Negative Control

Adrenal

Negative

Negative

Brain, Cerebellum

Negative

Negative

Brain, Cerebrum

Negative

Negative

Breast

Negative

Negative

Bone Marrow

Negative

Negative

Colon

Negative

Negative

Esophagus

Negative

Negative

Eye

Negative

Negative

Hypophysis

Moderate cytoplasmic staining
observed in hypophyseal cells (1/3)

Negative

Kidney

Negative

Negative

Larynx

Negative

Negative

Liver

Negative

Negative

Lung

Negative

Negative

Mesothelium

Negative

Negative

Ovary

Negative

Negative

Pancreas

Negative

Negative

Parathyroid

Negative

Negative

Peripheral Nerve

Negative

Negative

Prostate

Negative

Negative

Salivary Gland

Negative

Negative

Skin

Negative

Negative

Small Intestine

Negative

Negative

Spleen

Negative

Negative

Stomach

Weak cytoplasmic staining observed in
gastric glands (2/3)

Negative

Striated Muscle

Negative

Negative

Testis

Negative

Negative

Thymus

Negative

Negative

Thyroid

Negative

Negative

Tonsil

Negative

Negative

Uterine Cervix

Negative

Negative

Uterus

Negative

Negative

Table 9. Normal Panel Staining

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