Integra LifeSciences Collagen Wound Dressing, HeliTape, HeliCote, HeliPlug - Manual (Page 3)

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The sponge structure of the Absorbable Collagen Wound Dressings
provides a three-dimensional matrix for additional strengthening of
the blood clot.
In vivo studies using guinea pigs showed that the incidence of
infection (abscess) of incision sites inoculated with Staphylococcus
aurous was not enhanced by the presence of the Absorbable
Collagen Wound Dressings when compared to another collagen
hemostatic agent. However, extent of wound infection tended to be
greater than control with the Absorbable Collagen Wound Dressings
and another collagen hemostatic agent tested. This tendency is
observed with many foreign substances.
The Absorbable Collagen Wound Dressings for Dental Surgery have
been tested for potential allergenic sensitivity and cytotoxicity.
The sponges contain no toxic leachables, do not produce tissue
irritation, and show no contact sensitization upon repeat challenge.
Passive hemagglutination, which is a sensitive test for potential
antigenicity, was used with the Absorbable Collagen Wound
Dressings as the antigen. There was no agglutination observed.
The Absorbable Collagen Wound Dressings for Dental Surgery are
tested and certified as nonpyrogenic.
Indications
The Absorbable Collagen Wound Dressings for Dental Surgery are
indicated for application to moist or bleeding clean oral wounds
created during dental surgery, to control bleeding and protect the
surface of the wound from further injury. Topical administration of
the Absorbable Collagen Wound Dressings directly over the wound
effectively controls bleeding usually within two to five minutes.