GE Healthcare Marquette 12SL ECG - Manual (Page 2)

Clinically validated improvements
Any change to an analysis program requires a great deal
of research and validation. The Marquette 12SL ECG
analysis program is continually refined through the
following processes:
• Regular clinical input – Continuous input is gathered
from some of the world’s top consulting cardiologists
and physicians. This input helps to focus our research
and development efforts.
• Clinically correlated “Gold-Standard” databases –
GE utilizes different databases during the development
and validation processes to enhance program accuracy.
This precludes us from developing an analysis program
that works well on a training set of ECGs, but cannot be
applied with the same success to other populations.
• Beyond Gold-Standard databases – Clinically-correlated
databases help to improve program accuracy, but they
also have limitations. Analysis programs must work with
a wider spectrum of ECG data. To accomplish this task,
GE measures its analysis program performance on a large
database of ECGs (>50,000). This process challenges the
program with multiple diseases and varying degrees of
abnormality. ECGs with changed analysis results due to
program modification can be further investigated with
expert confirmation.
The result of all this work is improved program accuracy,
which in turn helps clinicians to improve patient care.
A complete suite of state-of-the-art ECG analysis
With the Marquette 12SL’s arrhythmia and chest pain
assessment capabilities, gender-specific criteria and risk
stratification tools, a wider range of disease management
needs can be addressed. This means physicians are assisted
in making more efficient and informed clinical decisions.
Ongoing development by one of the industry’s leading
advanced development staff provides the latest in capabilities.
Validation against global, clinically-verified databases offers
verified accuracy with multiple patient populations.
• Serial ECG comparison † – The Marquette 12SL ECG Analysis
Program and the Marquette Serial Comparison Program
provide a consistent analysis and comparison of waveforms
across each and every ECG, helping to ensure reproducibility
and objectivity through all phases of patient care.
– Provides department supervisors with a means to run
efficient operations.
– Utilizes interpretive statements, ECG measurements
and waveform comparison techniques to maximize
performance and accuracy in the detection of
clinically-significant changes.
– Emulates the techniques used by trained
electrocardiographers when comparing serial ECGs.
• Gender-Specific criteria – Marquette 12SL with Gender-
Specific interpretation applies criteria for evaluating the
ST segment and T wave of the ECG waveform, improving
sensitivity to acute myocardial infarction in women and
enhancing diagnostic confidence.
– Improved the sensitivity for detection of acute anterior
MI from 42% to 48% in women under 60 years of age. 1
– 25% relative improvement in detection of acute inferior
MI in women under 60 years of age without sacrificing
the high specificity already maintained by the program.
2
• Experience in QT measurement accuracy – Identifying
prolonged QT is important as the condition can result in
serious arrhythmia and Sudden Cardiac Death. However,
it can be difficult to measure QT accurately due to factors
like ECG noise, difficulty defining the end of the T wave, and
requiring corrections for heart rate. GE has concentrated its
efforts in helping to minimize these challenges through the
12SL program:
– 12SL measures QT from a median complex, resulting
in a cleaner representative complex for measurement
– Uses global fiducial points from all 12 simultaneous
leads for consistency, reproducibility, and accuracy
– When the Marquette Hookup Advisor * program is used
prior to acquiring the ECG to determine a quality signal,
QT interval measurement accuracy has been shown
to improve
3
– Offers multiple QT correction factors including Bazett,
Framingham †† , and Fridericia ††
By using all leads of the median complex to define the end of ventricular
repolarization, 12SL offers accuracy and consistency in QT measurement