Samsung UN46ES6100GXZE - Manual (Page 204)

in the PIP mode, the PIP function is
reset to Off . When you turn your TV
on, you must turn PIP on again to
watch in the PIP mode.
N You may notice that the picture in
the PIP screen becomes slightly
unnatural when you use the main
screen to view a game or karaoke.
N PIP does not work when the 3D
function is active.
N PIP Settings: The picture from the