Apple IIe Card - Manual (Page 154)

My Apple IIe program won’t start up from an Apple 5.25 Drive
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Make sure the disk drive is a gray Apple 5.25 Drive. (The earlier beige
models are not compatible with the Apple IIe Card.)
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Make sure the disk drive is connected correctly to the Macintosh LC.
(See Chapter 1 for instructions.)
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If you are using a UniDisk 3.5 Drive and an Apple 5.25 Drive, make
sure the disk drives are correctly daisy-chained together, with the
UniDisk 3.5 Drive first in the chain. (See Chapter 1 for instructions.)
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Make sure you’ve assigned the Apple 5.25 Drive to the correct
location in the Slot Configuration panel—slot 6.
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Change the Speed setting in the General Controls panel to Normal.
(Some copy-protection schemes prevent a program from running at
the Fast setting.)
Appendix A: Troubleshooting 138