Q3 Innovations DrugHAWK ECO Cup - Manual

Test
Amphetamine(AMP)
Barbiturates(BAR)
Benzodiazepines(BZO)
Cocaine(COC)
Marijuana(THC)
Methadone(MTD)
Methamphetamine(mAMP)
MDMA (Ecstasy)
Opiate 300 (OPI 300,MOP,MOR)
Opiate 2000 (OPI 2000)
Oxycodone (OXY)
Phencyclidine (PCP)
Tricyclic Antidepressants (TCA)
Calibrator
D-Amphetamine
Secobarbital
Oxazepam
Benzoylecgonine
11-nor- ∆ 9 -THC-9 COOH
Methadone
D-Methamphetamine
D,L-Methylenedioxymethamphetamine
Morphine
Morphine
Oxycodone
Phencyclidine
Nortriptyline
Cut-off
1,000 ng/mL
300 ng/mL
300 ng/mL
300 ng/mL
50 ng/mL
300 ng/mL
1,000 ng/mL
500 ng/mL
300 ng/mL
2,000 ng/mL
100 ng/mL
25 ng/mL
1,000 ng/mL
phased removal of methadone is an acceptable method of detoxification for patients and
therapists.
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The ECO CUP™ One Step Drug Test yields a positive result when the Methadone in urine
exceeds 300 ng/mL.
METHAMPHETAMINE (mAMP)
Methamphetamine is an addictive stimulant drug that strongly activates certain systems in the
brain. Methamphetamine is closely related chemically to amphetamine, but the central nervous
system effects of Methamphetamine are greater. Methamphetamine is made in illegal laboratories
and has a high potential for abuse and dependence. The drug can be taken orally, injected, or
inhaled. Acute higher doses lead to enhanced stimulation of the central nervous system and
induce euphoria, alertness, reduced appetite, and a sense of increased energy and power.
Cardiovascular responses to Methamphetamine include increased blood pressure and cardiac
arrhythmias. More acute responses produce anxiety, paranoia, hallucinations, psychotic behavior,
and eventually, depression and exhaustion. The effects of Methamphetamine generally last 2-4
hours and the drug has a half-life of 9-24 hours in the body. Methamphetamine is excreted in the
urine as amphetamine and oxidized and delaminated derivatives. However, 10-20% of
Methamphetamine is excreted unchanged. Thus, the presence of the parent compound in the
urine indicates Methamphetamine use. Methamphetamine is generally detectable in the urine for
3-5 days, depending on urine pH level.
The ECO CUP™ One Step Drug Test yields a positive result when the Methamphetamine in
urine exceeds 1,000 ng/mL.
MDMA (Ecstasy)
Methylenedioxymethamphetamine (ecstasy) is a designer drug first synthesized in 1914 by a
German drug company for the treatment of obesity.8 Those who take the drug frequently report
adverse effects, such as increased muscle tension and sweating. MDMA is not clearly a stimulant,
although it has, in common with amphetamine drugs, a capacity to increase blood pressure and
heart rate. MDMA does produce some perceptual changes in the form of increased sensitivity to
light, difficulty in focusing, and blurred vision in some users. Its mechanism of action is thought to
be via release of the neurotransmitter serotonin. MDMA may also release dopamine, although the
general opinion is that this is a secondary effect of the drug (Nichols and Oberlender, 1990). The
most pervasive effect of MDMA, occurring in virtually all people who took a reasonable dose of the
drug, was to produce a clenching of the jaws.
The ECO CUP™ One Step Drug Test yields a positive result when the
Methylenedioxymethamphetamine in urine exceeds 500 ng/mL.
OPIATE (OPI 300,MOP,MOR)
Opiate refers to any drug that is derived from the opium poppy, including the natural products,
morphine and codeine, and the semi-synthetic drugs such as heroin. Opioid is more general,
referring to any drug that acts on the opioid receptor.
Opioid analgesics comprise a large group of substances which control pain by depressing the
central nervous system. Large doses of morphine can produce higher tolerance levels,
physiological dependency in users, and may lead to substance abuse. Morphine is excreted
unmetabolized, and is also the major metabolic product of codeine and heroin. Morphine is
detectable in the urine for several days after an opiate dose.
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The ECO CUP™ One Step Drug Test yields a positive result when the concentration of opiate
exceeds the 300 ng/mL cut-off level.
OPIATE (OPI 2000)
Opiate refers to any drug that is derived from the opium poppy, including the natural products,
morphine and codeine, and the semi-synthetic drugs such as heroin. Opioid is more general,
referring to any drug that acts on the opioid receptor.
Opioid analgesics comprise a large group of substances which control pain by depressing the
central nervous system. Large doses of morphine can produce higher tolerance levels,
physiological dependency in users, and may lead to substance abuse. Morphine is excreted
unmetabolized, and is also the major metabolic product of codeine and heroin. Morphine is
detectable in the urine for several days after an opiate dose.
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The ECO CUP™ One Step Drug Test yields a positive result when the morphine in urine exceeds
2,000 ng/mL. This is the suggested screening cut-off for positive specimens set by the Substance
Abuse and Mental Health Services Administration (SAMHSA, USA).
OXYCODONE (OXY)
O x y c o d o n e ,
[ 4 , 5 - e p o x y - 1 4 - h y d r o x y - 3 - m e t h o x y - 1 7 - m e t h y l - m o r p h i n a n - 6 - o n e ,
dihydrohydroxycodeinone] is a semi-synthetic opioid agonist derived from thebaine, a constituent
of opium. Oxycodone is a Schedule II narcotic analgesic and is widely used in clinical medicine.
The pharmacology of oxycodone is similar to that of morphine, in all respects, including its abuse
and dependence liabilities. Pharmacological effects include analgesia, euphoria, feelings of
relaxation, respiratory depression, constipation, papillary constriction, and cough suppression.
BARBITURATES (BAR)
Barbiturates are central nervous system depressants. They are used therapeutically as sedatives,
hypnotics, and anticonvulsants. Barbiturates are almost always taken orally as capsules or tablets.
The effects resemble those of intoxication with alcohol. Chronic use of barbiturates leads to
tolerance and physical dependence. Short acting Barbiturates taken at 400 mg/day for 2-3 months
can produce a clinically significant degree of physical dependence. Withdrawal symptoms
experienced during periods of drug abstinence can be severe enough to cause death. Only a
small amount (less than 5%) of most Barbiturates are excreted unaltered in the urine.
The approximate detection time limits for Barbiturates are:
Short acting (e.g. Secobarbital) 100 mg PO (oral) 4.5 days
Long acting (e.g. Phenobarbital) 400 mg PO (oral) 7 days
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The ECO CUP™ One Step Drug Test yields a positive result when the Barbiturates in urine
exceed 300 ng/mL.
BENZODIAZEPINES (BZO)
Benzodiazepines are medications that are frequently prescribed for the symptomatic treatment of
anxiety and sleep disorders. They produce their effects via specific receptors involving a
neurochemical called gamma aminobutyric acid (GABA). Because they are safer and more
effective, Benzodiazepines have replaced barbiturates in the treatment of both anxiety and
insomnia. Benzodiazepines are also used as sedatives before some surgical and medical
procedures, and for the treatment of seizure disorders and alcohol withdrawal.
Risk of physical dependence increases if Benzodiazepines are taken regularly (e.g., daily) for
more than a few months, especially at higher than normal doses. Stopping abruptly can bring on
such symptoms as trouble sleeping, gastrointestinal upset, feeling unwell, loss of appetite,
sweating, trembling, weakness, anxiety and changes in perception.
Only trace amounts (less than 1%) of most Benzodiazepines are excreted unaltered in the urine;
most of the concentration in urine is conjugated drug. The detection period for the
Benzodiazepines in the urine is 3-7 days.
The ECO CUP™ One Step Drug Test yields a positive result when the Benzodiazepines in urine
exceed 300 ng/mL.
COCAINE (COC)
Cocaine is a potent central nervous system (CNS) stimulant and a local anesthetic. Initially, it
brings about extreme energy and restlessness while gradually resulting in tremors, over-sensitivity
and spasms. In large amounts, cocaine causes fever, unresponsiveness, difficulty in breathing and
unconsciousness.
Cocaine is often self-administered by nasal inhalation, intravenous injection and free-base
smoking. It is excreted in the urine in a short time primarily as Benzoylecgonine.
1.2
Benzoylecgonine, a major metabolite of cocaine, has a longer biological half-life (5-8 hours) than
cocaine (0.5-1.5 hours), and can generally be detected for 24-48 hours after cocaine exposure.
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The ECO CUP™ One Step Drug Test yields a positive result when the cocaine metabolite in
urine exceeds 300 ng/mL. This is the suggested screening cut-off for positive specimens set by
the Substance Abuse and Mental Health Services Administration (SAMHSA, USA).
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MARIJUANA (THC)
THC (
∆ 9 -tetrahydrocannabinol) is the primary active ingredient in cannabis (marijuana). When
smoked or orally administered, THC produces euphoric effects. Users have impaired short term
memory and slowed learning. They may also experience transient episodes of confusion and
anxiety. Long-term, relatively heavy use may be associated with behavioral disorders. The peak
effect of marijuana administered by smoking occurs in 20-30 minutes and the duration is 90-120
minutes after one cigarette. Elevated levels of urinary metabolites are found within hours of
exposure and remain detectable for 3-10 days after smoking. The main metabolite excreted in the
urine is 11-nor-
∆ 9 -tetrahydrocannabinol-9-carboxylic acid ( ∆ 9 -THC-COOH).
The ECO CUP™ One Step Drug Test yields a positive result when the concentration of THC-
COOH in urine exceeds 50 ng/mL. This is the suggested screening cut-off for positive specimens
set by the Substance Abuse and Mental Health Services Administration (SAMHSA, USA).
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METHADONE (MTD)
Methadone is a narcotic analgesic prescribed for the management of moderate to severe pain and
for the treatment of opiate dependence (heroin, Vicodin, Percocet, Morphine). The pharmacology
of Oral Methadone is very different from IV Methadone. Oral Methadone is partially stored in the
liver for later use. IV Methadone acts more like heroin. In most states you must go to a pain clinic
or a Methadone maintenance clinic to be prescribed Methadone. Methadone is a long acting pain
reliever producing effects that last from twelve to forty-eight hours. Ideally, Methadone frees the
client from the pressures of obtaining illegal heroin, from the dangers of injection, and from the
emotional roller coaster that most opiates produce. Methadone, if taken for long periods and at
large doses, can lead to a very long withdrawal period. The withdrawals from Methadone are more
prolonged and troublesome than those provoked by heroin cessation, yet the substitution and
One Step Drug Test
Package Insert for Multi Drug Screen Test cup
This Instruction Sheet is for testing of any combination of Amphetamine, Barbiturates, Benzodiazepines, Cocaine,
Marijuana, Methadone, Methamphetamine, Methylenedioxymethamphetamine, Morphine, Oxycodone,
Phencyclidine and Tricyclic Antidepressants.
Including Adulterant Tests (Specimen Validity Tests) for:
Oxidants (OX), Specific Gravity (S.G) and pH.
A rapid, one step screening test for the simultaneous, qualitative detection of multiple drugs and drug metabolites
in human urine.
For Professional and In Vitro Diagnostic Use Only.
INTENDED USE
The ECO CUP™ One Step Drug Test is a lateral flow chromatographic immunoassay for the
qualitative detection of multiple drugs and drug metabolites in urine at the following cut-off concentrations:
Configurations of the ECO CUP™ One Step Drug Test can consist of any combination of the above listed
drug analytes. This assay provides only a preliminary qualitative test result. Use a more specific alternate
quantitative analytical method to obtain a confirmed analytical result. Gas chromatography/mass spectrometry
(GC/MS) is the preferred confirmatory method.1 Apply clinical and professional judgment to any drug of abuse
test result, particularly when preliminary positive results are obtained.
SUMMARY AND EXPLANATION OF THE TEST
The ECO CUP™ One Step Drug Test is a competitive immunoassay utilizing highly specific reactions
between antibodies and antigens for the detection of multiple drugs and drug metabolites in human urine.
The
ECO CUP™ One Step Drug Test is a rapid urine screening test that utilizes monoclonal
antibodies to selectively detect elevated levels of specific drugs in urine without the use of an instrument.
AMPHETAMINE(AMP)
Amphetamine is a Schedule II controlled substance available by prescription (Dexedrine®) and is
also available on the illicit market. Amphetamines are a class of potent sympathomimetic agents
with therapeutic applications. They are chemically related to the human body's natural
catecholamines: epinephrine and norepinephrine. Acute higher doses lead to enhanced
stimulation of the central nervous system and induce euphoria, alertness, reduced appetite, and a
sense of increased energy and power. Cardiovascular responses to Amphetamines include
increased blood pressure and cardiac arrhythmias. More acute responses produce anxiety,
paranoia, hallucinations, and psychotic behavior. The effects of Amphetamines generally last 2-4
hours following use, and the drug has a half-life of 4-24 hours in the body. About 30% of
Amphetamines are excreted in the urine in unchanged form, with the remainder as hydroxylated
and deaminated derivatives.
The ECO CUP™ One Step Drug Test yields a positive result when Amphetamines in urine
exceed 1,000 ng/mL. This is the suggested screening cut-off for positive specimens set by the
Substance Abuse and Mental Health Services Administration (SAMHSA, USA).
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Y031
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