Chemical resistance of freeze dryer components, Drying chamber or drying manifold installation – Labconco FreeZone 1 Liter Benchtop Freeze Dry Systems 7740071 User Manual

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Chapter 3: Getting Started

Product Service: Domestic 1-800-522-7658, International 816-333-8811

Drying Chamber or Drying Manifold
Installation


The drying chamber or drying manifold, purchased separately, may
be positioned directly above the 3-inch hole in the collector
chamber lid. When vacuum is applied to the system, the chamber
will be held securely in place.

Chemical Resistance of Freeze
Dryer Components

The FreeZone Freeze Dry System is designed to be chemically
resistant to most compounds that are commonly used in freeze
drying processes. However, by necessity, the freeze dryer is
comprised of a number of different materials, some of which may
be attacked and degraded by certain chemicals. The degree of
degradation is dependent on the concentration and exposure
duration. Some of the major components of the FreeZone Freeze
Dry System that are susceptible to degradation are as follows:

Acids

Buffers

Solvents












Component












Material

Acetic Acid 20

%

Formic Acid

Trifluo

roa

cetic Acid

(TFA)

Ca

lcium Chloride

Sodium

Ph

os

phate

Acetone

Acetonittirle

C

arbon Tet

rochlo

ride

Cycl

ohe

xane

D

iox

ane

Methy

l t-Butyl

Ether (BTBE)

Pyridine

Valve

Stem Acetal

C

D

D

D

D

Collector
Lid

Acrylic

D

D

D

D

Hoses,
Gaskets &
Valve
Bodies

Neoprene

C D D C C D D D C D

Flask Top

Silicon
Rubber

C D D D D D C D

Chamber &
Fittings

Stainless
Steel

C

C – Moderate degradation; Limited use
D – Severe degradation; Infrequent use recommended; Immediate
thorough cleaning required.

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