HP Storage Mirroring V4.5 Software - Manual (Page 70)

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When you have finished configuring the optional protection options, continue with Validate the
Configuration on page 9-1.
NOTE: If you close the Application Manager prior to enabling protection, your changes will not
be saved. You must enable protection in order to save your configuration settings for a
source/target pair.
If you modify your configuration on the source server (such as adding a new storage
group or database to a directory that was not included in the replication set), you must
disable protection, run validation and fix any issues, then re-enable protection to apply
the changes to the Application Manager replication set.