HP Storage Mirroring V4.5 Software - Manual (Page 86)

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When you have finished configuring the optional protection options, continue with Validate the
Configuration on page 9-1.
NOTE: If you close the Application Manager prior to enabling protection, your changes will not
be saved. You must enable protection in order to save your configuration settings for a
source/target pair.
If you modify your configuration on the source server (such as adding a new storage
group or database), you must disable protection, run validation and fix any issues, then
re-enable protection to apply the changes to the Application Manager replication set.