Metrohm 700 Dosino - Manual (Page 43)

4. Appendix
700 Dosino, Instructions for Use 37
4 Appendix
4.1 Validation / GLP
Among other things, GLP (Good Laboratory Practice) requires the
regular checking of the precision and correctness of analytical in-
struments by means of
SOPs (Standard Operating Procedure).
Recommended literature
• Metrohm brochure "Quality management with Metrohm", de-
tailed information about the principles and procedures of Good
Laboratory Practice
• Metrohm Application Bulletin 238/1 "Dosimat test according to
GLP/ISO"
• Metrohm Application Bulletin 252/1 "Validation of Metrohm ti-
trators according to GLP/ISO9001"
Dosino burets can be validated in several different ways.
• Metrodata «Dosing Test» software (6.6025.000) for Win-
dows
® 3.11/95/NT
PC program for computer-controlled validation of Metrohm
dosing units and exchange units. Apart from a normal personal
computer this requires the use of a Metrohm Titrino and either
a Sartorius or Mettler analytical balance.
• Metrohm 711 Liquino
The 711 Liquino has a GLP mode which can be used for the
automatic validation of dosing units. The balances of the fol-
lowing distributos are supported: Mettler-Toledo, Sartorius,
AND, Precisa.
• Manual validation
Manual validation can be carried out with any Metrohm instru-
ment which supports the 700 Dosino. Metrohm Application
Bulletin 238/1 describes the procedure in detail.