Waters AccellPlus QMA and CM Bulk Media - Manual (Page 4)

[ Care and Use ManUal ]
Waters AccellPlus QMA and CM Bulk Media 4
f. Trouble Shooting
Problem Cause Remedy
Poor Resolution Sample overload Reduce sample amount (see Bulk Media Packing).
Flow rate too high Reduce flow rate.
Media fouling Reverse flow direction. Flush with suitable cleaning agent (see Chemical Compatibility).
Column voiding Check efficiency, and if low, repack or fill column void.
Low Flow Rate Media fouling Reverse flow direction. Flush with suitable cleaning agent (see Chemical Compatibility).
Frits plugged Reverse flow. Replace connector frits.
Low Capacity Salt concentration too high Reduce salt concentration.
pH too high (QMA) Lower pH if protein stability is not affected.
pH too low (CM) Raise pH if protein stability is not affected.
Inappropriate buffer salt Change buffer salt.