Integra LifeSciences Sutures, Plain and Chromic Gut, Absorbable - Manual

PLAIN and CHROMIC GUT SUTURE
ABSORBABLE SURGICAL SUTURES, U.S.P.
Description
Plain and Chromic Gut Suture is absorbable sterile suture composed of purified connective tissue (mostly
collagen) derived from the serosal layer of beef (bovine) intestines. They are packaged in a solution of 90%
Isopropyl Alcohol 0.5% Sodium Benzoate, 0.5% Diethylethanolamine, q.s. and 100% Pure Distilled Water. Chromic
gut is treated with chromic salt solution.
Plain and Chromic Gut Suture meets all requirements established by the United States Pharmacopeia (USP) for
Natural Absorbable Surgical Suture.
Indications
Plain and Chromic Gut Suture is indicated for use in general soft tissue approximation and/or ligation, including
use in ophthalmic procedures, but not for use in cardiovascular and neurological procedures.
Actions
When Plain and Chromic Gut Suture is placed in tissue, a moderate tissue inflammation occurs characteristic
of foreign body response to a substance. This is followed by a loss of tensile strength and suture mass, as the
proteolytic enzymatic digestive process dissolves the surgical gut. This process continues until the suture is
completely absorbed. Many variable factors may affect the rate of absorption. Some of the major factors, which can
affect tensile strength loss and absorption rates are:
1. Type of suture-Plain gut generally is expected to absorb more rapidly than chromic gut.
2. Infection-Surgical gut is absorbed more rapidly in infected tissue than in non-infected tissue.
3. Tissue Sites-Surgical gut will absorb more rapidly in tissue where increased levels of proteolytic enzymes are
present, as in the secretions exhibited in the stomach, cervix and vagina.
Contraindications
The use of this suture is contraindicated in patients with known sensitivities or allergies to collagen or chromium,
as gut is a collagen based material, and chromic gut is treated with chromic salt solutions.
Warnings
Do not resterilize. Discard open, unused sutures. Store at room temperature. Avoid prolonged exposure to elevated
temperatures.
As with any foreign body, prolonged contact of this or any other suture with salt solutions, such as those found in
the urinary or biliary tracts, may result in calculus formation.
This suture, being absorbable, should not be used where extended approximation of tissue is required.
Users should be familiar with surgical procedures and techniques involving gut suture before using Plain and
Chromic Gut Suture for wound closure, as risk of wound dehiscence may vary with the site of application and the
suture material used.
Instructions for Use