Epson Progression U12 - Manual (Page 129)

3. Remove the four screws securing the drive to the internal
drive bay. Then lift the drive out of the bay and set it aside.
Note
If you removed one IDE hard disk drive and are leaving
another one in the system, you must set the jumpers on
the remaining drive to indicate that you have only one
IDE drive installed. Remove the other drive following
steps 2 and 3, above; then see page 4-4 and the
documentation that came with your hard disk drive for
instructions on setting the jumpers.
4. If you removed your only IDE hard disk drive, you need to
remove the hard disk drive cable from the connector on the
main system board. First remove the cable from the clasps
on the side of the subassembly. Then disconnect the cable
from the main system board connector. (gee the illustration
on page 4-21 to locate the connector.)
If you removed the subassembly to perform any of the steps
above, follow the instructions in Chapter 2 to replace the
subassembly in the computer.
4-26 Installing and Removing Drives