ZOLL Thermogard XP IVTM Physician Manual - Manual (Page 10)

ZOLL IVTM™ System Physicians' Manual
600248-001 Rev 3 9
Exogenous pyrogens are polypeptides of origin external to endogenous pyrogens but
of similar action.
Cerebral Injury
Sustained changes in the thermoregulatory set-point are observed with irritation or
compression (tumor) of the hypothalamus. In addition, intra-cerebral release of
endogenous pyrogens (cerebral inflammation) can have the same effect. The
hypothalamus is exposed to cerebrospinal fluid as well as to blood, so it can be
subject to the action of CSF-borne pyrogens [2].