Labconco Purifier Filtered PCR Enclosures 3970425 - Manual (Page 27)

Chapter 5: Appropriate Applications for Your Filtered PCR Enclosure
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HEPA filters are only effective for entrapment of particulate matter. The
surface of the HEPA filter is fragile and should not be touched. Care must be
taken to avoid puncturing the HEPA filter during installation. If you suspect
that a HEPA filter has been damaged, DO NOT use the enclosure. See
Chapter 6 for Replacing the HEPA Filter.

The HEPA filter will gradually accumulate airborne particulate matter from
the room. The rate of accumulation will depend upon the cleanliness of the
room air, and the amount of time the enclosure is operating. With normal
usage, the HEPA filters will last two to five years before requiring
replacement.