MSI RD480 Neo2 - Manual (Page 101)

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Introduction to Realtek ALC 880
W hen you are playing the first audio source (for example: use W indows
Media Player to play DVD/VCD), the output will be played from the rear panel, which
is the default setting.
Then you must to select the Realtek HDA 2nd output from the scroll list
first, and use a different program to play the second audio source (for example: use
W inamp to play MP3 files). You will find that the second audio source (MP3 music) will
come out from the Line-Out audio jack of Front Panel.