Epson Epson - Manual (Page 137)

2. Remove the four screws (two on each side) securing the drive
to the drive bay. Then slide the drive out through the front
of the bay
3. If you are not installing an externally accessible drive in the
open drive bay, you need to install a faceplate for that bay.
Push the faceplate into the open bay until the tabs on the
plate click into place.
6-16 Installing and Removing Tower Drives