Leica Biosystems SM2500 - Manual (Page 53)

If the knife holder cannot be turned, it
has been misaligned. - In that case,
loosen all 8 clamping screws and re-
tighten as described on page 50.
6. Retighten any one of the rear clamping screws
(5) to secure the knife holder in that position.
Prior to inserting the knife always
tighten one of the rear clamping screws
to secure the knife holder position!
Put on cut-resistant gloves (see also
chapter. 8.1 ‘Additional accessories’).
7. Insert the knife with the writing pointing up-
wards (i.e. pointing backwards when being
inserted).
8. Tighten knife clamping screws (8) with an Allen
key size 8 starting with the center screws and
working your way outwards from side to side.
Only tighten as many screws as the knife is
actually wide.
Do not misalign the knife when tight-
ening the knife clamping screws (8).
This will negatively affect sectioning
results!
9. Place knife guard (7) over the knife edge.
10. Loosen rear clamping screw (5).
11. Turn the knife holder into the desired clearance
angle position (see p. 47 for details on the clear-
ance scale) and hold it in that position.
12. Lightly retighten one of the rear clamping
screws and let go of the knife holder.
13. Tighten remaining clamping screws (5) alter-
nately and lightly.
14. Tighten all clamping screws (5, 6) alternately.
5. Operation
53 Leica SM2500
8 5
7