Leica Biosystems PELORIS_PELORIS II - Manual (Page 10)

Safety Notices
Leica PELORIS™ User Manual Rev K © Leica Biosystems Melbourne Pty Ltd 2011 10
General Warnings and Cautions
Persons operating the Peloris must be fully aware of the following warnings, in order to mitigate possible tissue damage or
loss.
Reagent Configuration
Replacing Reagents
Protocol Validation
Basket and Cassette Loading
Cleaning Protocol
WARNING
Always ensure that the reagents configured in the software are the actual reagents loaded on the instrument.
A station containing different reagent could damage tissue samples.
WARNING
Always change reagents when prompted.
Always update station details correctly – never update the details without replacing the reagent.
Failure to follow these directives can lead to tissue damage or loss.
WARNING
Do not alter the concentration of a used reagent unless you are able to verify the actual concentration. If the
concentration is incorrect a reduction in tissue processing quality or damage to the tissue sample may result.
WARNING
Do not set new protocols as validated until they have passed the validation procedures for your laboratory.
Only then should you edit the protocol to set it as valid, making it available to operators for clinical use (
see
4.1.4 Protocol Validation). Use of nonvalidated protocols may result in tissue damage or loss.
WARNING
Always ensure the cassettes are correctly inserted into the baskets and that the baskets are correctly placed in
the retorts. Incorrectly placed cassettes or baskets may lead to samples being damaged as some tissue may not
be fully covered by reagent during processing (see 2.2.4 Cassette Baskets).
WARNING
Never place three baskets into a retort when the instrument is configured with a two-basket fill level. If this
occurs, reagent will not cover the top basket and tissue samples will be damaged.
WARNING
Remove all tissue from the retort before running a cleaning protocol as the dry step will damage the tissue.