2 sim method – INFICON HAPSITE ER Chemical Identification System User Manual
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HAPSITE ER Operating Manual
11.3.2 SIM Method
The SIM Analyze (GC/MS) method is used for the identification and quantitation of
only specific (or Target) compounds expected to be in the sample.
This type of analysis should be used where the highest sensitivity (lowest minimum
detectable concentration) is required, and where the compounds to be measured
are known. The SIM Analyze (GC/MS) method might include one or many specific
compounds for which the instrument will be calibrated.
This work may be carried out with just the HAPSITE, or a Laptop, Service Module,
HSS, SituProbe, and/or sample conditioning probe may be used. Regardless of the
configuration, certain method elements must be defined and set-up procedures
must be carried out. The method elements are:
If the HAPSITE is to operate separate from the Service Module, the HAPSITE
must have a NEG Pump installed and activated. Refer to
, or
for additional
information.
The quantitation sequence method must be defined. This includes the
definition of:
the Data File (where the data will be stored)
the Selected Ion Method parameters (which defines the masses to be
monitored and the elution times expected)
the Library Search parameters (which designates which library file to
access, individual and collective peak search, integration parameters, and
various reporting options)
the Inlet method file (which defines the temperatures, timing, and other gas
chromatograph and head space parameters)
the Tune/calibration file (which defines the mass spectral response to the
Target Compounds and the Internal Standards)
The instrument must be tuned, either with the AutoTune or Manual Tune
program. (Refer to
The instrument must be calibrated to the Target Compounds. (See
CAUTION
Temperature settings are critical to get the proper results.
Only trained users should modify these.